Réaction #2006476

Équation de réaction

acetone cyanohydrin

3-amino-1-propanol

→

desired compound 3

Rendement 71.0%

2-(3-Hydroxy-propylamino)-2-methyl-proprionitrile

Rendement 71.0%

Conditions de réaction

Traitement

1. 1
   Autreevaporated

Mode opératoire

To a neat solution of acetone cyanohydrin (930 mg, 10.9 mmol) at 0° C. was slowly added the 3-amino-1-propanol (861 mg, 11.5 mmol). The resulting solution was stirred at room temperature for 3 hrs and then evaporated under reduce pressure to give the desired compound 3 (1.1 g, 71%) which was directly used for the next step without purification.

Source