Réaction #2006423

Équation de réaction

4-vinyl-benzoic acid

benzenethiol

VAZO

→

white solid

Rendement 85.0%

4-(2-Thiophenyl)-ethyl Benzoic Acid

Rendement 85.0%

Solvants

benzene

Conditions de réaction

Traitement

1. 1
   AutreAccording to the published procedure (Gareau et al., Tet. Lett., 1994, 1837), under nitrogen atmosphere in a 50 mL round bottomed flask
2. 2
   Températureat reflux
3. 3
   Autrethe solvent was evaporated under vacuo
4. 4
   AutreThe solid was purified by trituration

Mode opératoire

According to the published procedure (Gareau et al., Tet. Lett., 1994, 1837), under nitrogen atmosphere in a 50 mL round bottomed flask containing 4-vinyl-benzoic acid (1.0 g, 6.75 mmoles) in 10 mL of benzene (0.7 M) was added benzenethiol (797 μL, 7.76 mmoles) followed by VAZO™ (Aldrich Chemical Company, 495 mg, 2.02 mmoles). The mixture was stirred for 12 hours at reflux. The resulting solution was cooled at room temperature and the solvent was evaporated under vacuo. The solid was purified by trituration using hexane and dichloromethane to afford 1.94 g (85%) of white solid.

Source