Réaction #2005

Équation de réaction

water

2-propanol

4-tolylboronic acid

2-bromo-1-nitrobenzene

→

product

Rendement 77.4%

4-Methyl-2'-nitro-1,1'-biphenyl

Rendement 77.4%

Solvants

sodium hydroxide

benzene

Conditions de réaction

Traitement

1. 1
   TempératureThe two-phase mixture was heated
2. 2
   Températureat reflux for three hours
3. 3
   AutreThe cooled reaction mixture
4. 4
   Filtrationwas filtered through Celite
5. 5
   Lavagethe filter cake washed with fresh benzene
6. 6
   AutreThe organic layer was separated
7. 7
   Lavagewashed with water (3×)
8. 8
   Séchagedried over magnesium sulfate
9. 9
   Filtrationfiltered
10. 10
    AutreThe filtrate was evaporated under vacuum
11. 11
    Autrethe residue (46.1 g) purified by preparative high pressure liquid chromatography on silica gel
12. 12
    Lavageeluting with hexane/ethyl acetate (20:1)

Mode opératoire

A vigorously stirred mixture of 34 g (0.25 mol) of 4-tolylboronic acid and 34 g (0.17 mol) of 2-bromo-1-nitrobenzene in a mixture of 170 mL of 5N sodium hydroxide, 57 mL of water, 215 mL of 2-propanol and 1080 mL of benzene was treated with 11.9 g of (tetrakis)triphenylphosphine palladium(0). The two-phase mixture was heated at reflux for three hours. The cooled reaction mixture was filtered through Celite and the filter cake washed with fresh benzene. The organic layer was separated and washed with water (3×), dried over magnesium sulfate and filtered. The filtrate was evaporated under vacuum and the residue (46.1 g) purified by preparative high pressure liquid chromatography on silica gel, eluting with hexane/ethyl acetate (20:1), to give 28.05 g of the product.

Source