Réaction #1994292

Équation de réaction

6-Amino-5-chloro-2-(4-chloro-2-fluorophenyl)pyrimidine-4-carboxylic acid methyl ester

sodium hydroxide

HCl

→

title compound

Rendement 44.7%

6-Amino-5-chloro-2-(4-chloro-2-fluorophenyl)pyrimidine-4-carboxylic acid

Rendement 44.7%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   ConcentrationThe resulting solution was concentrated
2. 2
   Autrethe precipitate that formed
3. 3
   Filtrationwas filtered
4. 4
   Lavagewashed with water
5. 5
   Autredried

Mode opératoire

6-Amino-5-chloro-2-(4-chloro-2-fluorophenyl)pyrimidine-4-carboxylic acid methyl ester (400 mg, 1.26 mmol) was dissolved in 10 mL methanol and 2 mL of 2N sodium hydroxide (4 mmol) was added. The reaction mixture was stirred at room temperature for 4 hours and then acidified with a slight excess of 2N HCl. The resulting solution was concentrated and the precipitate that formed was filtered, washed with water, and dried yielding the title compound (170 mg, 44% yield): mp 194-196° C.: 1H NMR (DMSO-d6+few drops of D2O): δ 7.92 (m, 1H), 7.54 (dd, 1H), 7.42 (dd, 1H).

Source