Réaction #1994258

Équation de réaction

10-(biphenyl-4-yl)-9,10-dihydroacridine

bromosuccinimide

→

10-(biphenyl-4-yl)-2-bromo-9,10-dihydroacridine

Rendement 77.7%

Solvants

chloroform

Conditions de réaction

Traitement

1. 1
   Lavagethe resultant solution was washed with distilled water
2. 2
   ExtractionThen, an organic layer was extracted
3. 3
   Séchagedried with sodium sulfate so as
4. 4
   Autreto remove the solvent
5. 5
   AutreThe residue was purified by silica gel column chromatography (methylene chloride/n-hexane (1/20))

Mode opératoire

The obtained 10-(biphenyl-4-yl)-9,10-dihydroacridine (15.3 g, 45.9 mmol) was added with chloroform (500 ml), and then with bromosuccinimide (9.8 g, 55.1 mmol). The resultant solution was stirred at room temperature for 2 hours. After the reaction was completed, the resultant solution was washed with distilled water. Then, an organic layer was extracted and dried with sodium sulfate so as to remove the solvent. The residue was purified by silica gel column chromatography (methylene chloride/n-hexane (1/20)) to obtain 10-(biphenyl-4-yl)-2-bromo-9,10-dihydroacridine compound (white solid, 14.7 g, yield 77%).

Source