Réaction #1994252

Équation de réaction

water

carbazole

sodium hydroxide

allylbromide

→

N-Allylcarbazole

Solvants

dimethylsulfoxide

Conditions de réaction

Traitement

1. 1
   Extractionextracted with ethyl acetate
2. 2
   LavageThe ethyl acetate layer was washed with water
3. 3
   Concentrationconcentrated
4. 4
   AutreThe crude product was purified

Mode opératoire

A mixture of 10.85 g (65.0 mmol) of carbazole, 2.60 g (65.0 mmol) of sodium hydroxide and 6.1 mL (72.0 mmol) of allylbromide in 100 mL dimethylsulfoxide was heated to 60° C. for 5 hours. The reaction mixture was poured into water and extracted with ethyl acetate. The ethyl acetate layer was washed with water and then concentrated. The crude product was purified using column chromatography (silica, 1:4 dichloromethane:hexane). Yield: 9.85 g (73%).

Source