Réaction #1986

Équation de réaction

compound

1-benzyl-3-trifluoromethylpyrrolidine-3-methanol

pyridine

p-toluenesulfonyl chloride

pyridine

→

title compound

1-benzyl-3-trifluoromethyl-3-(toluenesulfonyloxymethyl)pyrrolidine

Solvants

methylene chloride

Conditions de réaction

Traitement

1. 1
   Lavagewashed with water and brine
2. 2
   Autredried
3. 3
   AutreRemoval of the solvent

Mode opératoire

The compound from step 456b (1.61 g) was dissolved in dry pyridine, and the solution was cooled to 0° C. To this was added 1.458 g of p-toluenesulfonyl chloride in 4 mL of dry pyridine, and the reaction was stirred at 0.C for 4 days. The mixture was diluted with 300 mL of methylene chloride, then washed with water and brine and dried. Removal of the solvent gave 2.81 g of the title compound.

Source