Réaction #1985

Équation de réaction

compound

1-benzyl-3-trifluoromethylpyrrolidine-3-carboxylic acid

LAH

→

title compound

Rendement 99.9%

1-benzyl-3-trifluoromethylpyrrolidine-3-methanol

Rendement 99.9%

Solvants

THF

Conditions de réaction

Traitement

1. 1
   AutreThe reaction was quenched by the sequential dropwise addition of 0.35 mL water, 0.35 mL of 15% NaOH and 1.3 mL of water
2. 2
   workup.STIRRINGthe mixture was stirred for 1 hour
3. 3
   Filtrationfiltered
4. 4
   AutreThe filtrate was dried
5. 5
   Concentrationconcentrated

Mode opératoire

The compound from step 456a (2.32 g) was dissolved in 60 mL of dry THF, 1.12 eq of LAH (1N in dry THF) was added, and the reaction was stirred under N2 for 3 hours. The reaction was quenched by the sequential dropwise addition of 0.35 mL water, 0.35 mL of 15% NaOH and 1.3 mL of water, then the mixture was stirred for 1 hour and filtered. The filtrate was dried and concentrated to give 2.2 g of the title compound.

Source