Réaction #1973934

Équation de réaction

alcohol

3-Hydroxy-3-methylbutyl 4-(trifluoromethyl)benzenesulfonate

H2O

acetyl chloride

→

crude product

2-Methyl-4-(4-(trifluoromethyl)phenylsulfonyloxy)butan-2-yl acetate

Solvants

methylene chloride

methylene chloride

Conditions de réaction

Traitement

1. 1
   AutreThe reaction on completion
2. 2
   Lavagewashed with saturated sodium bicarbonate (2×10 mL), brine (1×10 mL)
3. 3
   Autredried
4. 4
   AutreThe solvent is evaporated

Mode opératoire

To a mixture of the alcohol 4 (0.500 g, 1.6 mmol), ZrOCl28.H2O (0.0025 g, 0.5 mol %) in methylene chloride (5 mL), acetyl chloride (0.251 g, 3.2 mmol) is added and the reaction is stirred for overnight at 20° C. The reaction on completion, is diluted with methylene chloride (5 mL) and washed with saturated sodium bicarbonate (2×10 mL), brine (1×10 mL) and dried. The solvent is evaporated to get the crude product. 1H NMR (400 MHz, CDCl3) δ1.56 (d, J=8.0, 6H), 1.60 (d, J=8.0, 5H), 2.14 (t, J=6.8, 2H), 4.33 (t, J=6.8, 2H), 7.82 (d, J=8.1, 2H), 8.04 (d, J=8.0, 2H).

Source