Réaction #1973924

Équation de réaction

Bupivacaine hydrochloride

sodium hydroxide

→

Bupivacaine

Solvants

water

Conditions de réaction

Traitement

1. 1
   Autreto precipitate the Bupivacaine base
2. 2
   FiltrationThe precipitated product was filtered
3. 3
   Lavagefurther washed with DI water for at least three times
4. 4
   AutreThe precipitated product was dried at ca. 40° C. in vacuum for 24 hours

Mode opératoire

Bupivacaine hydrochloride (Sigma-Aldrich Corporation, St. Louis, Mo.) was dissolved in de-ionized (DI) water at a concentration of 40 mg/ml (saturation). A calculated amount of sodium hydroxide (in the form of 1 N solution) was added to the solution and the pH of the final mixtures was adjusted to ten to precipitate the Bupivacaine base. The precipitated product was filtered, and further washed with DI water for at least three times. The precipitated product was dried at ca. 40° C. in vacuum for 24 hours.

Source