Réaction #1960536

Équation de réaction

potassium iodide

p-toluenesulfonylchloride

ethylene glycol

→

2-hydroxyethyl-p-toluenesulfonate

Rendement 29.7%

Solvants

methylene chloride

Conditions de réaction

Traitement

1. 1
   FiltrationInsoluble matters were filtered out of the reaction mixture
2. 2
   Lavagewere washed with ethyl acetate
3. 3
   Concentrationthe mixture was concentrated
4. 4
   AutreThe resulting crude product was purified by flash silica gel column chromatography (elution solvent: hexane/ethyl acetate=1/1)

Mode opératoire

621 mg (corresponding to 10.0 mmol) of ethylene glycol was dissolved in 100 mL of methylene chloride. To this solution under an ice bath, 3.49 g (corresponding to 15.0 mmol) of silver oxide, 350 mg (corresponding to 2.1 mmol) of potassium iodide and 2.10 g (corresponding to 11.0 mmol) of p-toluenesulfonylchloride were added. The resulting mixture was stirred at 0° C. for 2 hours. Insoluble matters were filtered out of the reaction mixture, and were washed with ethyl acetate. The washings were combined with the filtrate, and the mixture was concentrated. The resulting crude product was purified by flash silica gel column chromatography (elution solvent: hexane/ethyl acetate=1/1) to obtain 643 mg (corresponding to 2.97 mmol) of 2-hydroxyethyl-p-toluenesulfonate (FIG. 1-3, Step 3).

Source