Réaction #1960508

Équation de réaction

8-ethoxy-5,6-difluoro-3-(4-propylcyclohexyl)-3H-benzo[f]chromene

→

8-ethoxy-5,6-difluoro-3-(4-propylcyclohexyl)-2,3-dihydro-1H-benzo[f]chromene

Solvants

THF

Conditions de réaction

Traitement

1. 1
   FiltrationThe reaction solution is filtered
2. 2
   Autrethe filtrate is evaporated to dryness
3. 3
   AutreThe residue is recrystallised from ethyl acetate

Mode opératoire

5.1 g (13.1 mmol) of 8-ethoxy-5,6-difluoro-3-(4-propylcyclohexyl)-3H-benzo[f]chromene are hydrogenated at atmospheric pressure in THF and in the presence of Pd/C (5% of Pd). The reaction solution is filtered, and the filtrate is evaporated to dryness. The residue is recrystallised from ethyl acetate, giving 8-ethoxy-5,6-difluoro-3-(4-propylcyclohexyl)-2,3-dihydro-1H-benzo[f]chromene as a colourless solid (m.p. 158° C.).

Source