Réaction #1960506

Équation de réaction

6-ethoxy-3,4-difluoronaphthalen-2-ol

1-(4-propylcyclohexyl)prop-2-yn-1-ol

triphenylphosphine

DIAD

→

7-ethoxy-1,2-difluoro-3-[1-(4-propylcyclohexyl)prop-2-ynyloxy]naphthalene

Solvants

water

THF

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONare added over the course of 20 min with ice-
2. 2
   Températurecooling
3. 3
   Extractionthe mixture is extracted a number of times with MTBE
4. 4
   LavageThe combined organic phases are washed with water and saturated sodium chloride soln
5. 5
   Autre, and the solution is dried
6. 6
   Autreafter removal of the solvents
7. 7
   Autreis purified by column chromatography (SiO2, n-heptane:MTBE=2:1)
8. 8
   AutreThe further purification
9. 9
   Autreis carried out by recrystallisation from n-heptane

Mode opératoire

10.5 g (46.8 mmol) of 6-ethoxy-3,4-difluoronaphthalen-2-ol are initially introduced in 100 ml of THF together with 10.0 g (55.5 mmol) of 1-(4-propylcyclohexyl)prop-2-yn-1-ol and 15.0 g (57.2 mmol) of triphenylphosphine, and 11.5 ml (59.1 mmol) of DIAD are added over the course of 20 min with ice-cooling. After 18 h at RT, water is added, and the mixture is extracted a number of times with MTBE. The combined organic phases are washed with water and saturated sodium chloride soln., and the solution is dried using sodium sulfate. The residue remaining after removal of the solvents is purified by column chromatography (SiO2, n-heptane:MTBE=2:1). The further purification is carried out by recrystallisation from n-heptane, giving 7-ethoxy-1,2-difluoro-3-[1-(4-propylcyclohexyl)prop-2-ynyloxy]naphthalene as a yellowish solid.

Source