Réaction #1952946
ord-bf016e22225846a3a8f3a36c8e5887cd
Équation de réaction
Réactifs
Conditions de réaction
Traitement
- 1Autrewere prepared
- 2AutrePre-spray drying solutions
- 3Autrewere prepared
- 4ConcentrationFinal total solute concentration of the solution
- 5Autredrying
- 6Autrewas prepared
- 7workup.ADDITIONmixing the two solutions
- 8Autreto yield one liter of cosolvent with a total solute concentration of 1 g/L (w/v)
- 9ConcentrationHigher solute concentrations of 3 g/L (w/v)
- 10Autrewere prepared
- 11AutreThe solution was spray-dried
- 12workup.ADDITIONcontaining formulation
- 13Autrewas from about 110° C. to about 140° C.
- 14Autreranged from about 45-57° C.
Mode opératoire
The albuterol sulfate powder formulations listed in Table 7, were prepared as follows. Pre-spray drying solutions were prepared by dissolving the lipid in ethanol and albuterol sulfate and leucine in water. The ethanol solution was then mixed with the water solution at a ratio of 70/30 ethanol/water. Final total solute concentration of the solution used for spray drying varied from 1 g/L to 3 g/L. As an example, the DPPC/leucine/albuterol sulfate (76/16/8) spray drying solution was prepared by dissolving 760 mg of DPPC in 700 mL of ethanol, dissolving 160 mg leucine and 870 mg of albuterol sulfate in 300 mL water and then mixing the two solutions to yield one liter of cosolvent with a total solute concentration of 1 g/L (w/v). Higher solute concentrations of 3 g/L (w/v) were prepared by dissolving three times more of each solute in the same volumes of ethnaol and water. The solution was spray-dried as described above for the insulin containing formulation. Specifically, the inlet temperature was from about 110° C. to about 140° C., and the outlet temperature ranged from about 45-57° C.