Réaction #1951012

Équation de réaction

water

hydroxybenzaldehyde

caustic potash

1-bromopentadecane

→

p-pentadecanoxybenzaldehyde

Solvants

hexane

dimethylformamide

dimethylformamide

Conditions de réaction

Traitement

1. 1
   AutreA 100-ml four-necked flask was used
2. 2
   workup.ADDITIONwas dropped
3. 3
   Autrewhile being kept at 20° C.
4. 4
   workup.WAITaging was performed at 70° C. for 21 hours
5. 5
   Extractionextracted with toluene
6. 6
   LavageAfter washing with water, concentration
7. 7
   Autreto produce 11.03 g of slightly colored viscous liquid

Mode opératoire

A 100-ml four-necked flask was used, 2.79 g (42.3 mM) of 85-percent by weight caustic potash was suspended in 30 ml of dimethylformamide, and 10 ml of dimethylformamide solution containing 5.28 g (43.2 mM) of hydroxybenzaldehyde was dropped thereto while being kept at 20° C. or lower. Thereafter, aging was performed at 30° C. for 1 hour. Subsequently, 9.58 g (32.9 mM) of 1-bromopentadecane was added and aging was performed at 70° C. for 21 hours. The reaction solution was dispersed into water, and extracted with toluene. After washing with water, concentration is performed so as to produce 11.03 g of slightly colored viscous liquid. Subsequently, a recrystallization treatment was performed with hexane so as to produce 8.91 g (purity 98.3%) of p-pentadecanoxybenzaldehyde.

Source