Réaction #1929007

Équation de réaction

indole

sodium bisulfite

→

sodium indole-2-sulfonate

Solvants

ethanol

water

Conditions de réaction

Traitement

1. 1
   Autrethe synthesis of 5,6,7-trichlorogramine
2. 2
   FiltrationThe solid precipitate is filtered
3. 3
   Lavagewashed with ether
4. 4
   Autredried

Mode opératoire

FIG. 1b shows the synthesis of 5,6,7-trichlorogramine. A solution of indole (AA) in ethanol is added to a solution of sodium bisulfite in water. The mixture is stirred at room temperature for 12 hrs. The solid precipitate is filtered, washed with ether, and dried to yield sodium indole-2-sulfonate (BB) as a white solid. The sodium indole-2-sulfonate product (BB) is used in the next step without further purification. MP>320° C.; IR (KBr, cm−1) 3470, 3250, 1650, 1600, 1490, 1460, 1210, 1170, 1040, 760, 750.

Source