Réaction #1929
ord-61670ca8f3ee46f6b6f8d3342a1692cf
Équation de réaction
methyl (Z)-3-(3-nitrostyryl)-2-thiophenecarboxylate
acetic anhydride
→
methyl (Z)-3-(3-acetamidostyryl)-2-thiophenecarboxylate
Rendement 91.3%
Réactifs
Aucun
Conditions de réaction
Conditions détaillées
See reaction.notes.procedure_details.
Mode opératoire
Substantially the same procedure as in Reference Example 14 was repeated using methyl (Z)-3-(3-nitrostyryl)-2-thiophenecarboxylate obtained in Reference Example 13 (3.51 g, 12.1 mmol), and also using acetic anhydride (3.43 ml, 36.3 mmol) instead of trimethylacetyl chloride, to give methyl (Z)-3-(3-acetamidostyryl)-2-thiophenecarboxylate (3.33 g, 2 steps, 91.3%).