Réaction #1918924

Équation de réaction

7-(methoxycarbonylethyl)-1,2,3,5-tetrahydrocyclopenta[c]-quinolin-4-one

magnesium

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product

Rendement 22.0%

7-(Methoxycarbonylethyl)-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one

Rendement 22.0%

Solvants

methanol THF

Conditions de réaction

Traitement

1. 1
   FiltrationThe reaction mixture is filtered over glass fibers
2. 2
   Lavagethe filter residue is washed with dichloromethane-methanol
3. 3
   Concentrationthe combined filtrates are concentrated by evaporation in a vacuum
4. 4
   AutrePurification of the residue on silica gel

Mode opératoire

A solution of 550 mg (2.0 mmol) of 7-(methoxycarbonylethyl)-1,2,3,5-tetrahydrocyclopenta[c]-quinolin-4-one in 130 ml of methanol-THF 3:1 is mixed with 972 mg (40.0 mmol) of magnesium and stirred for 24 hours at room temperature. The reaction mixture is filtered over glass fibers, the filter residue is washed with dichloromethane-methanol, and the combined filtrates are concentrated by evaporation in a vacuum. Purification of the residue on silica gel yields 120 mg of product.

Source