Réaction #1909787

Équation de réaction

3,4-dichloro-2,4-dihydroxybenzoic acid

L-phenylalanine methyl ester hydrochloride

WSC.HCl

HOBT

→

title compound

Rendement 63.1%

N-(3,5-Dichloro-2,4-dihydroxybenzoyl)-L-phenylalanine methyl ester

Rendement 63.1%

Solvants

DMF

triethylamine

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONThen, the mixture was post-treated in the same manner as in the above Example 1, (Step 5)

Mode opératoire

To a solution of 3,4-dichloro-2,4-dihydroxybenzoic acid (17 g), L-phenylalanine methyl ester hydrochloride (19.8 g), WSC.HCl (17.6 g) and HOBT (12.4 g) in DMF (70 ml) was added dropwise triethylamine (12.8 ml) at room temperature, and the mixture was stirred for 16 hours. Then, the mixture was post-treated in the same manner as in the above Example 1, (Step 5) to give the title compound (18.32 g, yield 57%).

Source