Réaction #1905560

ord-372705e67c564752a3c5d0970938ffae

Équation de réaction

CCOC(=O)C(C)Sc1cnc(NC(=O)N(C2CCCCCC2)C2CCC2)s1
[2-(3-Cycloheptyl-3-cyclobutyl-ureido)-thiazol-5-ylsulfanyl]-propionic acid ethyl ester
C1CCCC(NC2CCC2)CC1
cycloheptyl-cyclobutylamine
CCOC(=O)CS.Nc1cncs1
5-aminothiazole 2-mercaptoacetic acid ethyl ester
→
O=C(O)CCSc1cnc(NC(=O)N(C2CCCCCC2)C2CCC2)s1
title compound
O=C(O)CCSc1cnc(NC(=O)N(C2CCCCCC2)C2CCC2)s1
3-[2-(3-Cyclobutyl-3-cycloheptyl-ureido)-thiazol-5-ylsulfanyl]-propionic acid

Réactifs

CCOC(=O)C(C)Sc1cnc(NC(=O)N(C2CCCCCC2)C2CCC2)s1
[2-(3-Cycloheptyl-3-cyclobutyl-ureido)-thiazol-5-ylsulfanyl]-propionic acid ethyl ester
C1CCCC(NC2CCC2)CC1
cycloheptyl-cyclobutylamine
CCOC(=O)CS.Nc1cncs1
5-aminothiazole 2-mercaptoacetic acid ethyl ester

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    AutreHydrolysis

Mode opératoire

[2-(3-Cycloheptyl-3-cyclobutyl-ureido)-thiazol-5-ylsulfanyl]-propionic acid ethyl ester prepared as described in general procedure (A) using cycloheptyl-cyclobutylamine and 5-aminothiazole-2-mercaptoacetic acid ethyl ester. Hydrolysis using general procedure (F) gave the title compound

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US07598391B2uspto-grants-2009_10