Réaction #1903

Équation de réaction

4-bromo-3-methoxyphenol

benzyl bromide

potassium carbonate

→

4-benzyloxy-2-methoxybromobenzene

Solvants

acetone

Conditions de réaction

Traitement

1. 1
   AutreThe insoluble materials were removed by filtration
2. 2
   Concentrationthe filtrate was concentrated in vacuo
3. 3
   AutreThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=20:1)

Mode opératoire

A mixture of 4-bromo-3-methoxyphenol (21 g), benzyl bromide (13.5 ml), potassium carbonate (21.4 g) and acetone (200 ml) was stirred at room temperature for 24 h. The insoluble materials were removed by filtration and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=20:1) to give 4-benzyloxy-2-methoxybromobenzene (25 g) as an oil.

Source