Réaction #1889

Équation de réaction

2-amino-5-chloro-α-(2-chlorophenyl)benzyl alcohol

trifluoroacetic acid

sodium hydrogen carbonate

→

crystal

Rendement 95.7%

5-chloro-α-(2-chlorophenyl)-2-(trifluoroacetylamino)benzyl alcohol

Rendement 95.7%

Solvants

dichloromethane

dichloromethane

Conditions de réaction

Traitement

1. 1
   AutreAfter reaction
2. 2
   Autrethe organic layer was dried
3. 3
   Autreafter which the solvent was removed
4. 4
   Autrethe residue was recrystallized from hexane

Mode opératoire

To a solution of 1.0 g of 2-amino-5-chloro-α-(2-chlorophenyl)benzyl alcohol in 12 ml of dichloromethane, a solution of 0.8 g of anhydrous trifluoroacetic acid in 2 ml of dichloromethane was added. After reaction, an aqueous solution of sodium hydrogen carbonate was added, and the organic layer was dried, after which the solvent was removed and the residue was recrystallized from hexane to yield 1.3 g of a crystal.

Source