Réaction #1861071

Équation de réaction

4-benzyl-1H-imidazole

K2CO3

Cs2CO3

methanesulfonic acid phenethyl ester

→

4-benzyl-1-phenethyl-imidazole

Solvants

ACN

Conditions de réaction

Traitement

1. 1
   TempératureThe reaction mixture is heated
2. 2
   Températureat reflux overnight
3. 3
   Filtrationfiltered
4. 4
   Lavagecake washed with ACN and filtrate
5. 5
   Concentrationconcentrated under reduced pressure
6. 6
   AutreThe residue is purified by silica gel chromatography

Mode opératoire

To a solution of 4-benzyl-1H-imidazole (example 110C) (1.23 g, 7.78 mmoles) in ACN (20 mL) are added K2CO3 (1.29 g, 9.34 mmoles), Cs2CO3 (253 mg, 0.778 mmole) and methanesulfonic acid phenethyl ester (example 4D) (1.86 g, 9.34 mmole). The reaction mixture is heated at reflux overnight, then cooled to room temperature, filtered, cake washed with ACN and filtrate concentrated under reduced pressure. The residue is purified by silica gel chromatography using (toluene:acetone) (90:10) to give 4-benzyl-1-phenethyl-imidazole.

Source