Réaction #1859547

Équation de réaction

Compound 202

(1S,2R)-4′-(4-chlorophenyl)-2-(methoxymethyl)-2′,3′,9′-trimethylspiro[cyclopropane-1,6′-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine]

5′-(4-chlorophenyl)-6′,7′-dimethylspiro[cyclobutane-1,3′-thieno[2,3-e][1,4]diazepin]-2′(1′H)-one 2,2,2-trifluoroacetate

→

4′-(4-chlorophenyl)-2′,3′,9′-trimethylspiro[cyclobutane-1,6′-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine]

Conditions de réaction

Mode opératoire

A procedure analogous to that set forth in the synthesis of Compound 202 (Step 6) was followed, with the exception that 5′-(4-chlorophenyl)-6′,7′-dimethylspiro[cyclobutane-1,3′-thieno[2,3-e][1,4]diazepin]-2′(1′H)-one 2,2,2-trifluoroacetate was used as starting material. LRMS (M+H)+: 383 m/z. 1H NMR (400 MHz, DMSO-d6) δ7.50 (s, 4H), 3.28-3.39 (m, 1H), 2.73-2.87 (m, 1H), 2.60 (s, 3H), 2.39 (s, 3H), 1.89-1.98 (m, 1H), 1.78-1.88 (m, 1H), 1.64-1.74 (m, 2H), 1.61 (s, 3H).

Source