Réaction #1857547

Équation de réaction

dichloro methane

sodium hydride

2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)but-3-en-2-ol

methyl iodide

→

desired compound

1-[2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-methoxy-but-3-enyl]-1,2,4-triazole

Solvants

Brine

THF

Conditions de réaction

Traitement

1. 1
   TempératureThe mixture was then heated for 10 h
2. 2
   Températureto reflux
3. 3
   Autrethe organic phase was dried
4. 4
   Autreevaporated
5. 5
   Autreto obtain the crude product
6. 6
   AutreThis was purified by column chromatography

Mode opératoire

2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)but-3-en-2-ol (0.4 g) was dissolved in THF (10 mL) and sodium hydride (0.03 g) was added. The mixture was stirred for 30 min at room temperature and methyl iodide (0.08 mL) was added. The mixture was then heated for 10 h to reflux. Brine and dichloro methane were added, the organic phase was dried and evaporated to obtain the crude product. This was purified by column chromatography to obtain 0.04 g of the desired compound.

Source