Réaction #1857546

Équation de réaction

hydrochloric acid

1,2,4-Triazole

2-bromo-1-[2-chloro-4-(4-chlorophenoxy)phenyl]ethanone

sodium hydride

→

desired material

Rendement 80.3%

1-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-(1,2,4-triazol-1-yl)ethanone

Rendement 80.3%

Solvants

water

THF

THF

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONwas added (3000 mL)
2. 2
   FiltrationThe precipitate was filtered off
3. 3
   Lavagewashed with MTBE
4. 4
   ConcentrationThe organic phase was then concentrated
5. 5
   Filtrationthe resulting solid was filtered off

Mode opératoire

1,2,4-Triazole (249 g) was added carefully (small portions) to a mixture of sodium hydride (85 g) in THF (6000 mL). After 30 minutes a solution of 2-bromo-1-[2-chloro-4-(4-chlorophenoxy)phenyl]ethanone (1322 g) in THF (500 mL) was slowly added and the mixture was stirred for 150 min. The pH was adjusted to 7 with dil. hydrochloric acid whereupon water was added (3000 mL). The precipitate was filtered off and washed with MTBE. The organic phase was then concentrated and the resulting solid was filtered off to yield the desired material (1008 g).

Source