Réaction #1857541

Équation de réaction

4-chlorophenol

2-chloro-4-fluoroacetophenone

potassium carbonate

→

1-[2-chloro-4-(4-chlorophenoxy)phenyl]ethanone

Solvants

DMF

Conditions de réaction

Traitement

1. 1
   Températurewas heated
2. 2
   Températureto reflux for 48 h
3. 3
   Autrethe reaction mixture was partitioned between MTBE and water
4. 4
   Extractionthe aqueous phase was extracted twice with MTBE
5. 5
   LavageThe combined organic phases were consecutively washed with 10% LiCl solution, dil. NaOH solution and water
6. 6
   Autredried
7. 7
   AutreThe solvent was evaporated under reduced pressure
8. 8
   Autrethe crude material was crystallized from diisopropyl ether

Mode opératoire

A mixture of 4-chlorophenol (186 g), 2-chloro-4-fluoroacetophenone (250 g) and potassium carbonate (238 g) in DMF (960 mL) was heated to reflux for 48 h. After cooling to room temperature, the reaction mixture was partitioned between MTBE and water and the aqueous phase was extracted twice with MTBE. The combined organic phases were consecutively washed with 10% LiCl solution, dil. NaOH solution and water and dried. The solvent was evaporated under reduced pressure and the crude material was crystallized from diisopropyl ether.

Source