Réaction #1840234

ord-0b997b6cf42344a68a60825571e39b94

Équation de réaction

CC(CO[Si](C)(C)C(C)(C)C)n1cc(I)c2cnccc21
1-(2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-3-iodo-1H-pyrrolo[3,2-c]pyridine
CON(C)C(=O)c1cc(Br)ccn1
4-bromo-N-methoxy-N-methylpyridine-2-carboxamide
→
CC(CO[Si](C)(C)C(C)(C)C)n1cc(C(=O)c2cc(Br)ccn2)c2cnccc21
(4-bromopyridin-2-yl)[1-(2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-1H-pyrrolo[3,2-c]pyridin-3-yl]methanone

Réactifs

CC(CO[Si](C)(C)C(C)(C)C)n1cc(I)c2cnccc21
1-(2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-3-iodo-1H-pyrrolo[3,2-c]pyridine
CON(C)C(=O)c1cc(Br)ccn1
4-bromo-N-methoxy-N-methylpyridine-2-carboxamide

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    AutrePrepared
  2. 2
    AutrePurified
  3. 3
    Lavageeluting with 35-40% EtOAc in hexane

Mode opératoire

Prepared according to the method described for Preparation 37 using 1-(2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-3-iodo-1H-pyrrolo[3,2-c]pyridine (Preparation 55) and 4-bromo-N-methoxy-N-methylpyridine-2-carboxamide. Purified using silica gel column chromatography eluting with 35-40% EtOAc in hexane.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US09163021B2uspto-grants-2015_10