Réaction #1810796

Équation de réaction

ethyl 3-hydroxybutyrate

ethyl 4-cyano-3-hydroxybutyrate

→

ethyl (R)-4-cyano-3-hydroxybutyrate

Rendement 99.0%

Conditions de réaction

Traitement

1. 1
   AutreAfter reaction for 3 hours

Mode opératoire

Instead of ethyl 3-hydroxybutyrate used in Example 1, ethyl 4-cyano-3-hydroxybutyrate (1%, w/v) was used as a reactant and novozyme 435 lipase was used as a biocatalyst. After reaction for 3 hours, ethyl (R)-4-cyano-3-hydroxybutyrate (99% e.e) was obtained at 57.3% conversion.

Source