Réaction #1797493

Équation de réaction

5-aminoindane

acetic anhydride

→

5-(N-acetylamino)indane

Rendement 84.6%

Solvants

—

ice water

acetic acid

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONAfter completion of the dropwise addition
2. 2
   AutreAfter completion of the reaction
3. 3
   Autrethe reaction liquid
4. 4
   workup.STIRRINGwhile stirring
5. 5
   AutreCrystals precipitated
6. 6
   Filtrationwere filtered off
7. 7
   Lavagewashed with 1,000 ml of water
8. 8
   AutreThe crystals obtained
9. 9
   Autrewere dried

Mode opératoire

33.3 g (0.25 mol) of 5-aminoindane (a product of Tokyo Chemical Industry Co. Ltd.) was dissolved in 250 ml of glacial acetic acid, the resulting solution was heated to 50° C., and 51.0 g (0.5 mol) of acetic anhydride was added dropwise thereto. After completion of the dropwise addition, the resulting solution was stirred for 4 hours. After completion of the reaction, the reaction liquid was poured in 1,500 ml of ice water while stirring. Crystals precipitated were filtered off, and washed with 1,000 ml of water. The crystals obtained were dried to obtain 37.06 g of 5-(N-acetylamino)indane (yield: 84.6%, melting point: 100.5 to 103.5° C.)

Source