Réaction #1788

Équation de réaction

2,4-dimethyl-3-hydroxymethylpyridine

thionyl chloride

→

2,4-dimethyl-3-chloromethylpyridine

Solvants

CH2Cl2

Conditions de réaction

Traitement

1. 1
   AutreThe solvent was removed under reduced pressure
2. 2
   Autrethe residue was partitioned between CH2Cl2 and saturated aqueous sodium bicarbonate
3. 3
   SéchageThe organic layer was dried with MgSO4
4. 4
   Filtrationfiltered
5. 5
   Autrethe solvent removed under reduced pressure

Mode opératoire

The 2,4-dimethyl-3-hydroxymethylpyridine (19.2 g, 140 mmol) was dissolved in CH2Cl2 (800 mL) and cooled under nitrogen to 0° C. and thionyl chloride (125 mL) was slowly added and the reaction was stirred for 18 hours. The solvent was removed under reduced pressure and the residue was partitioned between CH2Cl2 and saturated aqueous sodium bicarbonate. The organic layer was dried with MgSO4, filtered and the solvent removed under reduced pressure to give the desired 2,4-dimethyl-3-chloromethylpyridine.

Source