Réaction #1771990

ord-56238b79bf8e4876a8c816dff94dc2f6

Équation de réaction

CC1(C)CN(C(=O)OC(C)(C)C)[C@@](C(=O)O)(C(C)(C)C)C1
tert-butyl N-tert-butoxycarbonyl-4,4-dimethylproline
→
CC1(C)CN[C@H](C(=O)O)C1
4,4-Dimethylproline

Réactifs

CC1(C)CN(C(=O)OC(C)(C)C)[C@@](C(=O)O)(C(C)(C)C)C1
tert-butyl N-tert-butoxycarbonyl-4,4-dimethylproline

Réactifs

Aucun

Solvants

ClCCl
dichloromethane

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    ConcentrationThe solution was concentrated
  2. 2
    Autredried under high vacuum
  3. 3
    Autretaken to the next step without further purification

Mode opératoire

A solution of tert-butyl N-tert-butoxycarbonyl-4,4-dimethylproline in dichloromethane (5 mL) and trifluoroacetic (5 mL) was stirred at room temperature for five hours. The solution was concentrated, dried under high vacuum and taken to the next step without further purification.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: USRE043298E1uspto-grants-2012_04