Réaction #1764380

ord-591dc8301cbc459aba291ddaa976a13c

Équation de réaction

O=C(c1ccc(Br)cc1)C1CC1
(4-Bromo-phenyl)-cyclopropyl-methanone
O=C(O)c1ccc(B(O)O)cc1F
(4-carboxy-3-fluorophenyl)boronic acid
C[C@@H]1CCCN1C[C@@H]1CCCN1
2-(R)-Methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine
→
C[C@@H]1CCCN1C[C@@H]1CCCN1C(=O)c1ccc(-c2ccc(C(=O)C3CC3)cc2)cc1F
title compound
C[C@@H]1CCCN1C[C@@H]1CCCN1C(=O)c1ccc(-c2ccc(C(=O)C3CC3)cc2)cc1F
Cyclopropyl-{3′-fluoro-4′-[2-(S)-(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidine-1-carbonyl]-biphenyl-4-yl}-methanone

Réactifs

O=C(c1ccc(Br)cc1)C1CC1
(4-Bromo-phenyl)-cyclopropyl-methanone
O=C(O)c1ccc(B(O)O)cc1F
(4-carboxy-3-fluorophenyl)boronic acid
C[C@@H]1CCCN1C[C@@H]1CCCN1
2-(R)-Methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

The title compound is prepared in a manner substantially analogous to Procedures QQ and B′ starting from commercially available (4-Bromo-phenyl)-cyclopropyl-methanone and (4-carboxy-3-fluorophenyl)boronic acid (CAS#120153-08-4), then 2-(R)-Methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine. MS (M+H) 435.2

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08008301B2uspto-grants-2011_08