Réaction #1757537

ord-23f0c00114fe463a8e0c793b810b5775

Équation de réaction

OC[C@@H](O)[C@@H](O)CO
erythritol
CN1[C@@H]2CC(OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12
scopolamine HCl
→
CN1[C@@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@H]12
scopolamine HCl
CN1[C@@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@H]12
Scopolamine

Réactifs

OC[C@@H](O)[C@@H](O)CO
erythritol
CN1[C@@H]2CC(OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12
scopolamine HCl
—
casting solution

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    AutreA casting solution was prepared

Mode opératoire

A casting solution was prepared containing 4.0% CMC and 1.0% erythritol. A 10.0 mg aliquot of scopolamine HCl was dissolved into 50 g of the casting solution thereby yielding a scopolamine HCl concentration of 200 μg/g of the casting solution. A 1.2543 g amount of the casting solution containing the drug was equally divided between the three wells of the sample BP strip. PAM® was employed as a release agent. After 45 minutes in the IR drying tunnel the recovered weight was 105% of the theoretical NVS. The resulting films easily released from the casting well and were clear and flexible. Each film swatch averaged 22 mg and contained 8.4 μg of scopolamine HCl.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US07993674B2uspto-grants-2011_08