Réaction #1757083

Équation de réaction

1-Chloro-2-methylpropyl chloroformate

4-(Methylthio)phenol

4-methylmorpholine

→

title compound D4

1-Chloro-2-methylpropyl (4-methylthiophenoxy)formate

Solvants

dichloromethane

dichloromethane

Conditions de réaction

Traitement

1. 1
   Autrethe temperature below 15° C
2. 2
   workup.STIRRINGThe reaction mixture was then stirred at room temperature overnight
3. 3
   LavageThe reaction mixture was washed with water (2×100 mL)
4. 4
   Autrefollowed by evaporation to an oil

Mode opératoire

4-(Methylthio)phenol (28 g) and dichloromethane (100 mL) were charged to a vessel. The vessel was cooled to approximately 0° C. 1-Chloro-2-methylpropyl chloroformate (14 mL) was added. A solution of 4-methylmorpholine (24 g) in dichloromethane (100 mL) was then slowed added using an addition funnel, keeping the temperature below 15° C. The reaction mixture was then stirred at approximately 0° C. for 10 minutes. The reaction mixture was then stirred at room temperature overnight. The reaction mixture was washed with water (2×100 mL) followed by evaporation to an oil. Fifty-four grams (54 g) of the title compound D4 was obtained.

Source