Réaction #1747852

Équation de réaction

4-carboxyphenylthiourea

DIC

→

Phenylthiourea

Solvants

DMF

Conditions de réaction

Traitement

1. 1
   AutreAminopropylsilylated glass surfaces purified with compressed air (2.5×7.5 cm; Sigma, Silane-Prep™, S4651)
2. 2
   Autrethus obtained
3. 3
   workup.ADDITIONThe glass surfaces thus treated
4. 4
   Lavagewere then washed five times
5. 5
   Autrefor 3 minutes
6. 6
   Autreat room temperature
7. 7
   LavageAfter washing three times for three minutes each using respectively 30 mL of DCM at room temperature
8. 8
   Autrethe glass surfaces were dried
9. 9
   Autrestored at 4° C. until further use

Mode opératoire

4-carboxyphenylthiourea (Lancaster, 13047) was dissolved to 0.2M in DMF. The resultant mixture was activated by adding a half equivalent of DIC for 15 min at room temperature. Aminopropylsilylated glass surfaces purified with compressed air (2.5×7.5 cm; Sigma, Silane-Prep™, S4651) were coated with the activated solution thus obtained and incubated for three hours at room temperature. The glass surfaces thus treated were then washed five times using respectively 30 mL of DMF for 3 minutes each at room temperature. After washing three times for three minutes each using respectively 30 mL of DCM at room temperature, the glass surfaces were dried and stored at 4° C. until further use.

Source