Réaction #1726706

Équation de réaction

2-(N-Boc-amino)-3-phenyl-thiophene

N-chlorosuccinimide

→

2-(N-Boc-amino)-5-chloro-3-phenyl-thiophene

Rendement 66.6%

Solvants

dichloromethane

dichloromethane

Conditions de réaction

Traitement

1. 1
   Autreat 0° C.
2. 2
   Lavagewashed with water
3. 3
   Concentrationthe organic phase concentrated in vacuo

Mode opératoire

To 2-(N-Boc-amino)-3-phenyl-thiophene (89 mg, 0.32 mmol) in dichloromethane (4 ml) at 0° C. was slowly added N-chlorosuccinimide (48 mg, 0.36 mmol), and the mixture allowed warm to ambient temperature for 16 hr. The mixture was diluted with dichloromethane, washed with water, and the organic phase concentrated in vacuo. Flash chromatography on silica gel (ethyl acetate/hexanes) yielded 2-(N-Boc-amino)-5-chloro-3-phenyl-thiophene (66 mg, 66%).

Source