Réaction #1726705

Équation de réaction

5-amino-1-(3′-nitrophenyl)-4-cyanopyrazole

phosphoric acid

ammonium hydroxide

→

5-amino-1-(3′-nitrophenyl)-pyrazole

Rendement 80.0%

Conditions de réaction

Traitement

1. 1
   ExtractionThe organics were extracted three times with diethyl ether (total 40 ml)
2. 2
   Lavagewashed with brine
3. 3
   Séchagedried over magnesium sulfate
4. 4
   AutreRemoval of solvent

Mode opératoire

5-amino-1-(3′-nitrophenyl)-4-cyanopyrazole (559 mg, 2.44 mmol) and phosphoric acid (86%, 6 ml) were refluxed at 170° C. for 15 h. The reaction was cooled to room temperature and neutralized with ammonium hydroxide. The organics were extracted three times with diethyl ether (total 40 ml), washed with brine, and dried over magnesium sulfate. Removal of solvent gave 5-amino-1-(3′-nitrophenyl)-pyrazole as a yellow powder (398 mg, 80% yield).

Source