Réaction #1726701

Équation de réaction

ammonia

hydrazine

sulfonyl chloride

4-phenyl-5-phthalimido-thiazole

hydrazine

→

5-amino-2-(aminosulfonyl)-4-phenylthiazole

Rendement 36.0%

5-amino-4-phenylthiazole

Rendement 16.0%

Solvants

methanol

dichloromethane

Conditions de réaction

Traitement

1. 1
   ConcentrationAfter 10 min the mixture was concentrated in vacuo
2. 2
   Températureheated to reflux
3. 3
   Températurereflux
4. 4
   FiltrationThe cooled mixture was filtered
5. 5
   Concentrationconcentrated in vacuo

Mode opératoire

The crude mixture of sulfonyl chloride with 4-phenyl-5-phthalimido-thiazole (231 mg) in dichloromethane (10 ml) was treated with ammonia in methanol (900 μl, 2.0 M) dropwise at ambient temperature. After 10 min the mixture was concentrated in vacuo. The residue was suspended in ethanol (10 ml), treated with ethanolic hydrazine (660 μl, 1.0 M, 660 μmol) and heated to reflux. After 1.5 hr a further portion of ethanolic hydrazine was added (660 μl, 1.0 M, 660 mol) and reflux continued for 15 hr. The cooled mixture was filtered and concentrated in vacuo. Flash chromatography on silica gel (ethyl acetate/hexanes) yielded pure 5-amino-2-(aminosulfonyl)-4-phenylthiazole (56 mg, 36% for 3 steps) and 5-amino-4-phenylthiazole (17 mg, 16% for 3 steps).

Source