Réaction #1726674

Équation de réaction

hydrogen

methyl benzoyl formate

(−) cinchonidine

→

(R)-methyl mandelate

Rendement 99.7%

Solvants

toluene

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONwere mixed in an autoclave
2. 2
   Autrewas removed by filtration
3. 3
   Autreafter the reaction
4. 4
   ConcentrationThe filtrate was concentrated
5. 5
   Autrethe residue was purified

Mode opératoire

The cross-linked Ir—Pt cluster composition obtained in Example 13 (20.2 mg), methyl benzoyl formate (164.2 mg, 1.0 mmole), (−) cinchonidine (3.8 mg, 0.013 mmole) and toluene (5 ml) were mixed in an autoclave and agitated for five hours at room temperature in a hydrogen atmosphere at a pressure of 50 atmospheres. The cross linked Ir—Pt cluster composition was removed by filtration after the reaction. The filtrate was concentrated, and the residue was purified using PTLC to obtain (R)-methyl mandelate (165.6 mg, 99.7% yield). The asymmetric yield was 62.6% ee.

Source