Réaction #172124

Équation de réaction

dimethyl 4-(2-cyanovinyl)isophthalate

2-(methylamino)acetic acid

paraformaldehyde

2-(Methylamino)acetic acid

paraformaldehyde

→

title compound

Dimethyl 4-(trans-4-cyano-1-methylpyrrolidin-3-yl)isophthalate

Solvants

toluene

Conditions de réaction

Traitement

1. 1
   AutreThen the solution was transferred to another flask
2. 2
   Autreleaving the dark tar behind
3. 3
   TempératureThe reaction mixture was heated to 125° C. under nitrogen for another 2 hours
4. 4
   TempératureThen this was cooled
5. 5
   Concentrationconcentrated
6. 6
   Autrepartitioned between saturated NaHCO3(aq.) and ethyl acetate
7. 7
   LavageThe organic layer was washed with brine
8. 8
   Séchagedried over Na2SO4
9. 9
   Concentrationconcentrated
10. 10
    Autrepurified by flash column chromatography with 80-100% ethyl acetate/hexane

Mode opératoire

A 100 mL round bottom flask was charged with dimethyl 4-(2-cyanovinyl)isophthalate (380 mg, 1.55 mmol), 2-(methylamino)acetic acid (276 mg, 3.1 mmol), paraformaldehyde (326 mg, 10.85 mmol) and toluene (5 mL). The reaction mixture was heated to 125° C. under nitrogen for 2 hours. Then the solution was transferred to another flask leaving the dark tar behind. 2-(Methylamino)acetic acid (276 mg, 3.1 mmol) and paraformaldehyde (326 mg, 10.85 mmol) were added. The reaction mixture was heated to 125° C. under nitrogen for another 2 hours. Then this was cooled and concentrated and partitioned between saturated NaHCO3(aq.) and ethyl acetate. The organic layer was washed with brine, dried over Na2SO4, concentrated, and purified by flash column chromatography with 80-100% ethyl acetate/hexane to provide the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 8.30 (d, J=1.9, 1H), 8.13 (dd, J=2.0, 8.3, 1H), 7.81 (d, J=8.3, 1H), 4.43-4.33 (m, 1H), 3.89 (d, J=5.7, 3H), 3.36 (q, J=8.1, 1H), 3.30 (s, 3H), 3.20-3.10 (m, 1H), 3.02-2.92 (m, 1H), 2.75 (dd, J=6.4, 9.2, 1H), 2.62 (dd, J=5.5, 9.5, 1H), 2.34 (s, 3H); MS (ESI+) m/z 302.9 [M+H]+.

Source