Réaction #171355

ord-b3a70ef77559445e94eed95630cff817

Équation de réaction

Cc1cccc2sc(Cl)nc12
using intermediates 2b
Cc1cccc2sc(Cl)nc12
2-Chloro-4-methyl-benzothiazole
O=C(O)C(F)(F)F.O=S(=O)(Nc1ccccc1OCC1CCNC1)c1ccccn1
6b
O=C(O)C(F)(F)F.O=S(=O)(Nc1ccccc1OCC1CCNC1)c1ccccn1
N-(2-(pyrrolidin-3-ylmethoxy)phenyl)pyridine-2-sulfonamide trifluoroacetate
→
Cc1cccc2sc(N3CCC(COc4ccccc4NS(=O)(=O)c4ccccn4)C3)nc12
Compound 31
Cc1cccc2sc(N3CCC(COc4ccccc4NS(=O)(=O)c4ccccn4)C3)nc12
N-(2-((1-(4-methylbenzo[d]thiazol-2-yl)pyrrolidin-3-yl)methoxy)phenyl)pyridine-2-sulfonamide

Réactifs

Cc1cccc2sc(Cl)nc12
using intermediates 2b
Cc1cccc2sc(Cl)nc12
2-Chloro-4-methyl-benzothiazole
O=C(O)C(F)(F)F.O=S(=O)(Nc1ccccc1OCC1CCNC1)c1ccccn1
6b
O=C(O)C(F)(F)F.O=S(=O)(Nc1ccccc1OCC1CCNC1)c1ccccn1
N-(2-(pyrrolidin-3-ylmethoxy)phenyl)pyridine-2-sulfonamide trifluoroacetate

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

Compound 31 is prepared using synthesis method 3 using intermediates 2b and 6b (yield: 28%).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08846930B2uspto-grants-2014_09