Réaction #171353

ord-49532ce51c3d4671a878d4f73e6988f4

Équation de réaction

Clc1nc2ccc(Br)cc2s1
using intermediates 2d
Clc1nc2ccc(Br)cc2s1
6-Bromo-2-chloro-benzothiazole
O=C(O)C(F)(F)F.O=S(=O)(Nc1ccccc1OC1CCNCC1)c1ccccn1
6a
O=C(O)C(F)(F)F.O=S(=O)(Nc1ccccc1OC1CCNCC1)c1ccccn1
N-(2-(piperidin-4-yloxy)phenyl)pyridine-2-sulfonamide trifluoroacetate
→
O=S(=O)(Nc1ccccc1OC1CCN(c2nc3ccc(Br)cc3s2)CC1)c1ccccn1
Compound 27
O=S(=O)(Nc1ccccc1OC1CCN(c2nc3ccc(Br)cc3s2)CC1)c1ccccn1
N-(2-(1-(6-bromobenzo[d]thiazol-2-yl)piperidin-4-yloxy)phenyl)-pyridine-2-sulfonamide

Réactifs

Clc1nc2ccc(Br)cc2s1
using intermediates 2d
Clc1nc2ccc(Br)cc2s1
6-Bromo-2-chloro-benzothiazole
O=C(O)C(F)(F)F.O=S(=O)(Nc1ccccc1OC1CCNCC1)c1ccccn1
6a
O=C(O)C(F)(F)F.O=S(=O)(Nc1ccccc1OC1CCNCC1)c1ccccn1
N-(2-(piperidin-4-yloxy)phenyl)pyridine-2-sulfonamide trifluoroacetate

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

Compound 27 is prepared using synthesis method 3 using intermediates 2d and 6a (yield: 14%).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08846930B2uspto-grants-2014_09