Réaction #170514

Équation de réaction

6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid

4-amino-2-butanol

→

title compound

Rendement 90.0%

N-(3-Hydroxy-butyl)-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinamide

Rendement 90.0%

Conditions de réaction

Mode opératoire

As described for example 191, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid (200 mg, 0.65 mmol) was converted, using 4-amino-2-butanol instead of 2-aminoethyl isopropylether, to the title compound (221 mg, 90%) which was obtained as a white solid. MS: m/e=380.3 [M−H].

Source