Réaction #1701

Équation de réaction

diethyl 1-(6-chloro-1-oxoindan-2-yl)imidazole-2,4-dicarboxylate

ammonium acetate

acetic acid

→

ethyl 7-chloro-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-2-carboxylate

Rendement 61.7%

Solvants

acetonitrile

methanol

acetone

Conditions de réaction

Traitement

1. 1
   LavageAfter washing the precipitate with water
2. 2
   Autrewith methyl ethyl ketone, the solid obtained

Mode opératoire

The procedure is as in Example 1 but starting from 5 g of diethyl 1-(6-chloro-1-oxoindan-2-yl)imidazole-2,4-dicarboxylate, 118 g of ammonium acetate and 190 ml of acetic acid. After washing the precipitate with water and then with methyl ethyl ketone, the solid obtained is first of all ground in acetonitrile and then in methanol and finally in acetone to obtain 2.7 g of ethyl 7-chloro-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-2-carboxylate in the form of a brown solid melting above 260° C. (analysis % calculated C: 58.28, H: 3.67, Cl: 10.75, N: 12.74; % found C: 58.6, H: 3.4, Cl: 10.4, N: 13.1).

Source