Réaction #1698236

Équation de réaction

methyl salicylate

potassium carbonate

methyl 2-bromohexanoate

→

Methyl 2-(1-methoxycarbonylpentoxy)benzoate

Solvants

acetonitrile

Conditions de réaction

Traitement

1. 1
   TempératureThe colourless suspension was heated
2. 2
   Températureunder reflux
3. 3
   Filtrationthe suspension was filtered
4. 4
   Lavagethe residue was washed with acetone
5. 5
   AutreConcentration of the filtrate in vacuo resulted in 27.8 g (99% of theory) of methyl 2-(1-methoxycarbonylpentoxy)benzoate as yellow oil

Mode opératoire

15.2 g of methyl salicylate and 18.0 g of potassium carbonate were introduced into 125 ml of acetonitrile in a 250 ml flask under an argon atmosphere and, at room temperature, 20.9 g of methyl 2-bromohexanoate were added. The colourless suspension was heated under reflux with stirring for 16 hours, and the progress of the reaction was checked by thin-layer chromatography. After cooling to room temperature, the suspension was filtered and the residue was washed with acetone. Concentration of the filtrate in vacuo resulted in 27.8 g (99% of theory) of methyl 2-(1-methoxycarbonylpentoxy)benzoate as yellow oil.

Source