Réaction #169520

Équation de réaction

1-(2,2-difluoro-1,3-benzodioxol-5-yl)-cyclopropanecarboxylic acid

SOCl2

→

1-(2,2-difluoro-1,3-benzodioxol-5-yl)-cyclopropanecarbonyl chloride

Solvants

toluene

Conditions de réaction

Traitement

1. 1
   workup.DISTILLATIONThe toluene and SOCl2 are distilled from the reaction mixture after 30 minutes
2. 2
   workup.ADDITIONAdditional toluene (2.5 vol) is added
3. 3
   workup.DISTILLATIONdistilled again

Mode opératoire

1-(2,2-difluoro-1,3-benzodioxol-5-yl)-cyclopropanecarboxylic acid (1.2 eq) is slurried in toluene (2.5 vol) and the mixture heated to 60° C. SOCl2 (1.4 eq) is added via addition funnel. The toluene and SOCl2 are distilled from the reaction mixture after 30 minutes. Additional toluene (2.5 vol) is added and distilled again.

Source