Réaction #168338

Équation de réaction

Cyclopentene oxide

benzylamine

→

trans-2-(benzylamino)cyclopentanol

Solvants

EtOAc

Conditions de réaction

Traitement

1. 1
   Autremicrowaved at 150° C. for 3 hours
2. 2
   TempératureThe reaction mixture was then cooled
3. 3
   LavageThe organic layer was washed with water
4. 4
   Séchagedried over anhydrous Na2SO4
5. 5
   AutreEvaporation of the solvent
6. 6
   Autrein vacuo and purification on a silica gel column (0 to 20% MeOH/CH2Cl2)

Mode opératoire

Cyclopentene oxide (5.0 g, 59.1 mmol), benzylamine (7.0 g, 65.3 mmol) and titanium isopropoxide (3.40 g, 12.0 mmol) were taken in a microwave vial and microwaved at 150° C. for 3 hours. The reaction mixture was then cooled and diluted with EtOAc (100 mL). The organic layer was washed with water and dried over anhydrous Na2SO4. Evaporation of the solvent in vacuo and purification on a silica gel column (0 to 20% MeOH/CH2Cl2) afforded trans-2-(benzylamino)cyclopentanol. MS APCl calc'd for C12H17NO [M+H]+ 192. found 192.

Source