Réaction #1683

Équation de réaction

trifluoroacetic acid

Boc-D-Phe-Pro-OBn

anisole

→

white powder

Rendement 85.0%

D-Phe-Pro-OBn.TFA

Rendement 85.0%

Solvants

dichloromethane

Conditions de réaction

Traitement

1. 1
   Autrethe solvents were evaporated in vacuo
2. 2
   workup.DISSOLUTIONthe thick oily residue was dissolved in diethyl ether (1.5 L)
3. 3
   Autre(72 hours)
4. 4
   FiltrationThe white precipitate was filtered
5. 5
   Lavagewashed with diethyl ether (300 mL)
6. 6
   Autredried

Mode opératoire

To a stirring solution of Boc-D-Phe-Pro-OBn (68 g, 150 mmol) in dichloromethane (50 mL) at 0° C., was added anisole (20 mL) followed by trifluoroacetic acid (400 mL). After stirring for 3 hours, the solvents were evaporated in vacuo and the thick oily residue was dissolved in diethyl ether (1.5 L) and refrigerated (72 hours). The white precipitate was filtered, washed with diethyl ether (300 mL) and dried to yield 59.4 g (85%) of white powder.

Source