Réaction #167369

Équation de réaction

Bromine

1H-indole-4-carbonitrile

sodium metabisulphite

ethylacetate

→

3-Bromo-1H-indole-4-carbonitrile

Rendement 78.4%

Solvants

hexane

DMF

DMF

Conditions de réaction

Traitement

1. 1
   AutreThe precipitate was collected
2. 2
   Lavagewashed with cold water
3. 3
   Autredried

Mode opératoire

Bromine in DMF (0.796 g, 4.975 mmol) was added to a stirred solution of 1H-indole-4-carbonitrile (700 mg, 4.9295 mmol) in DMF (15 mL) at room temperature. The resulting mixture was stirred at room temperature for 2 hours. The reaction was monitored by TLC (10% ethylacetate in hexane). The reaction mixture was poured into ice water containing 0.5% ammonia and 0.5% sodium metabisulphite. The precipitate was collected, washed with cold water and dried to afford 850 mg of 3-Bromo-1H-indole-4-carbonitrile (78.41% yield).

Source